Blocking buffer for preventing non-specific binding of proteins during immunochemical applications Blocking buffer is used for the reduction of background interference during Western blotting. This buffer prevents non-specific binding of antibodies and enhances the sensitivity of any immunochemical applications by increasing signal-to-noise ratio and promoting specific binding of the primary antibody while minimizing non-specific interactions. This buffer comes as a ready-to-use solution of preformulated nonfat dry milk which is suitable for any immunochemical applications.