Human Recombinant Granulocyte Colony Stimulating Factor Source : E.coli Cell Culture Tested

recombinant human G-CSF expressed in E. coli, filtered through 0.22µ membrane filter and lyophilized without any additives. G-CSF is relatively specific for cells belonging to the neotrophil lineage, at higher concentrations it has some effect on multi-progenitor cells also. Human and murine G-CSF are species cross-reactive. Colony stimulating factors (CSFs) are a group of cell-derived cytokines responsible for proliferation and differentiation of progenitor cells. They bind to receptors on the surfaces of hematopoietic cells and then activate intracellular pathways which induce the cells to proliferate and differentiate into specific kind of blood cells. Colony stimulating factors include Granulocyte Colony Stimulating Factor (G-CSF), Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) and Macrophage Colony Stimulating Factor (M-CSF). Granulocyte Colony Stimulating Factor (G-CSF) is a proliferation, differentiation, survival and activation factor of hematopoietic cells of the restricted neutrophil granulocyte lineage. It is a powerful stimulator of mature human eosinophils and neutrophils. It binds to the transmembrane receptor G-CSFR (also called CD114) and induces intracellular signals . Although G-CSF is relatively specific for cells belonging to the neotrophil lineage, at higher concentrations it has some effect on multi-progenitor cells also. Human and murine G-CSF are species cross-reactive.