Human Recombinant Bone morphogenetic protein-2 Source : E.coli Cell Culture Tested

CF003 is a BMP-2 is a potent osteoinductive cytokine capable of inducing osteoblast differentiation in various cell types in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. BMP-2 is used to enhance osteogenic differentiation of human adipose-derived stromal cells and has been shown to induce chondrocyte formation also. Bone Morphogenetic Proteins (BMPs) form a unique group of proteins within Transforming Growth factor - β (TGF-β) superfamily. In cell culture applications, BMPs are important regulators of stem cell differentiation, maintenance, reprogramming and self-renewal, as well as carcinogenesis suppression. They bind to the cell surface receptors on mesenchymal stem cells and send signals to the cell nucleus which results in the synthesis of macromolecules involved in cartilage and bone formation and then the mesenchymal cell differentiates into chondrocytes or osteoblasts. BMPs induce signals through 3 types of transmembrane receptors namely BMPR1A, BMPR1B and BMPR2.